CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan.
Abstract
CYP-14 members of the Caenorhabditis elegans (C. elegans) Cytochrome P450 (CYP) enzyme family, plays important roles in mitochondrial dysfunction, detoxification, lipid metabolism, defense and lifespan regulation. The review identifies CYP-14 members: cyp-14A1, cyp-14A2, cyp-14A3, cyp-14A4, cyp-14A5 and their homology with human CYP families. Despite limited studies on C. elegans cyp-14 members, the findings unraveled their complex crosstalk between mitochondrial stress, detoxification mechanisms, and lifespan regulation, emphasizing the complexity of these interconnected pathways as well as how their regulation depends on environmental cues changes including pH, nutrients, ROS and chemical stressors. The review underscores the translational relevance to human health, shedding light on potential human homologues and their implications in age-related, metabolic and respiratory diseases. Among other genes, cyp-14A2 and cyp-14A4 predominate the mitochondrial function, heat resistance, lipid metabolism, detoxification and lifespan pathways. In conclusion, these insights pave the way for future research, offering promising avenues for therapeutic interventions targeting CYP-14 activity to address age-related diseases and promote healthy aging.
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Research summary
The paper discusses the role of CYP-14 family members in mitochondrial function, detoxification, and lifespan regulation in C. elegans, which is relevant to understanding mechanisms of aging and lifespan extension. However, the findings are based on limited studies and primarily focus on the crosstalk between various pathways without presenting novel experimental data or significant breakthroughs. Thus, while it contributes to the field, its impact is modest.
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