Probiotics Attenuate Myopathic Changes in Aging Rats via Activation of the Myogenic Stellate Cells.
Abstract
Aging represents a complex biological process associated with decline in skeletal muscle functions. Aging impairs satellite cells that serve as muscle progenitor cells. Probiotic supplementation may have many beneficial effects via various mechanisms. We examined the possible effects of probiotics in stimulating the proliferation of myogenic stellate cells in aging rats. Twenty-four male albino Sprague-Dawley rats were classified equally into four groups: adult control, old control, adult + probiotics, and old + probiotics. Probiotics (Lactobacillus LB) were administered gavage at a dose of 1 ml (1 × 10
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
Probiotics can stimulate the proliferation of myogenic stellate cells in aging rats. This research addresses a potential mechanism to mitigate age-related decline in muscle function, which is a significant aspect of the aging process.
Author of this paper? Send a correction.