Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys.

Jeong Hoon Park, Sung Gi Yoon, Jung Yeon Ghee, Ji Ae Yoo, Jin Joo Cha, Young Sun Kang, Sang Youb Han, Yun Jae Seol, Jee Young Han, Dae Ryong Cha

Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Republic of Korea.Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Republic of Korea. · pubmed

Paper

Abstract

Aging is a risk factor for development of chronic kidney disease and diabetes mellitus with commonly shared features of chronic inflammation and increased oxidative stress. Here, we investigated the effect of pan-Nox-inhibitor, APX-115, on renal function in aging diabetic mice.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the effects of a pan-Nox inhibitor on renal function in aging diabetic mice, which is relevant to aging and age-related diseases. However, it primarily focuses on treating symptoms of chronic kidney disease rather than addressing the root causes of aging or lifespan extension. The findings may contribute to understanding the management of kidney function in aging populations, but the impact on the broader field of longevity research is limited.

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