Normative Brain Entropy Across the Lifespan
Abstract
Brain entropy (BEN), a measure of the complexity and irregularity of neural has emerged as a promising marker for cognitive and clinical traits. However, normative lifespan trajectories of BEN remain underexplored. In this study, we investigated age-related changes in BEN across the human lifespan using Sample Entropy (SampEn). BEN was estimated from resting-state fMRI data collected from multiple Human Connectome Project cohorts (N = 2,415, ages 8-89 years), and normative growth curves were modeled using the GAMLSS framework. Results revealed a nonlinear increase in average BEN from childhood to older adulthood, with females exhibiting significantly higher BEN than males. Regional and network-level analyses confirmed similar age-related patterns.
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Research summary
The study claims that brain entropy increases nonlinearly from childhood to older adulthood, with notable differences between genders. This research is relevant as it explores normative brain changes across the lifespan, which could provide insights into cognitive aging and potential interventions for age-related cognitive decline.
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