Viral infections reduce Drosophila lifespan through accelerated aging

Gonzalez, R., Castello-Sanjuan, M., Saleh, M.-C.

Institut Pasteur, Université Paris Cité, Viruses and RNA Interference Unit (Paris, France)Institut Pasteur, Université Paris Cité, Viruses and RNA Interference Unit (Paris, France) · biorxiv

Paper

Abstract

Viral infections induce symptoms reminiscent of aging, but their impact on the host\'s biological age remains unclear. Using a computational approach, we estimated the biological age of Drosophila melanogaster flies infected with various enteric viruses and demonstrated that enteric viral infections accelerate biological aging. Comparative analysis revealed that more pathogenic viruses induced a faster increase in acceleration of aging.

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Research summary

Viral infections accelerate biological aging in Drosophila melanogaster. The study explores the relationship between viral infections and biological aging, which is directly relevant to understanding the mechanisms of aging and potential interventions.

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