The Relationship Between Biological Aging with Interdisciplinary Health Indicators: A Scoping Review

Reeves, J. T. H., Knock, E., Gilson, Z. M., Derry, L., McGhee, M. C., Taylor-Hood, K., Ziesel, A., Jabbari, H., Newton, L., Miller, J. A., Zhang, J., Rhodes, R., Mallidou, A., Paterson, T. S. E.

University of Victoria · medrxiv

Paper

Abstract

ObjectivesThis review aims to provide a comprehensive examination of biomarkers and interdisciplinary variables related to aging.

MethodsThis scoping review included studies which involved adult participants, and which reported on the relationship between any biomarker or biological age with chronological age.

ResultsAfter screening, 447 articles met the selection criteria. Results were categorized into 10 distinct categories through an iterative process.

ConclusionsThis review contributes information regarding the interdisciplinary influences on the rate of aging. Telomere length was the most commonly examined biomarker, and Horvaths 353-CpG Pan-Tissue clock was the most common clock, with both demonstrating a strong and consistent relationship with chronological age. The interdisciplinary variables demonstrated relationships with biological aging with varying strengths and consistencies.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper provides a scoping review of biomarkers and their relationship with biological aging, which is pertinent to the field of longevity research. However, while it categorizes existing studies and highlights common biomarkers, it does not present novel findings or solutions that significantly advance the understanding of aging mechanisms or interventions. Thus, its impact is limited to a solid contribution without groundbreaking implications.

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