ER-stress signaling and Alzheimer's proteins adjust the quality of human protein synthesis
Abstract
Proteostasis is the balance of protein synthesis, protein maintenance and protein degradation. Proteostasis is disturbed in neurodegenerative disorders like Alzheimer`s disease (AD) of the aging human body. Protein synthesis by the ribosome is the most error-prone process of gene expression. If and how the error-rate of protein synthesis is regulated during human aging and contributes to AD is unknown. Here we show that ribosomal error-rate is adapted in cellular models of human aging, but not mouse aging. This adaptation involves ER-stress signaling and the Alzheimer`s disease-related proteins amyloid-beta precursor protein and presenilin 1. Our results suggest that ribosomal error-rate is a relevant parameter in human aging and disease.
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Research summary
The paper claims that ribosomal error-rate is adapted in cellular models of human aging, implicating ER-stress signaling and Alzheimer's proteins. This research is relevant as it explores the mechanisms of protein synthesis errors in the context of human aging and Alzheimer's disease, potentially addressing underlying processes that contribute to age-related decline.
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