β-nicotinamide mononucleotide production in Vibrio natriegens: a preliminary study

Tran, L. H., Tran, P. V. T., Pham, D. H. T., Nguyen, G. T., Nghiem, T. T., Pham, A. D., Pham, N. Q., Le, T. T., Nguyen, L. N., Dang, M. T. N., Tran, T. H., Tran, K. V., Le, H. Q.

School of Chemistry and Life Sciences, Hanoi University of Science and Technology · biorxiv

Paper

Abstract

Nicotinamide mononucleotide (NMN), is a promising nutraceutical attracting much attention for its pharmacological and anti-aging efficacies. However, NMN-containing commercial products are very high-priced due to the lack of efficient and facile methods for industrial-scale production. To date, various metabolic engineering strategies have been successfully applied to produce NMN in Escherichia coli. Recently, Vibrio natriegens has become a promising host in the bioindustry thanks to its rapid growth and capabilities of broad substrate utilization. This study aims to evaluate the NMN biosynthesis capability of V. natriegens.

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Research summary

This study evaluates the capability of Vibrio natriegens to produce β-nicotinamide mononucleotide (NMN). The paper is relevant as it explores a potential method for producing a compound (NMN) that is associated with anti-aging effects and longevity research.

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