Mitochondria-nucleus communication dictates progressive versus bimodal aging of the mammary gland.

Jenkins, E. C., Chattopadhyay, M., Mashaka, T., Polushakov, D., Torres-Martin, M., Sia, D., Bado, I., Germain, D.

Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount Sinai · biorxiv

Abstract

Non-linear aging, identified through oscillations in human plasma proteomics around 44 and 60, is postulated to contribute to the onset of diseases. Incidence of breast cancer follows such bimodal pattern. We show that mitochondria-nucleus matching in mice results in two mammary gland aging patterns, including a bimodal pattern associated with susceptibility to mammary tumor and that this bimodal signature is enriched in breast cancer patients diagnosed at 45 and 65.

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Research summary

Mitochondria-nucleus communication influences distinct aging patterns in the mammary gland, which may be linked to breast cancer susceptibility. The study addresses mechanisms of aging and their connection to disease, aligning with the exploration of root causes of aging.

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