Markers, Mechanisms and Metrics of Biological Aging: A Scoping Review
Abstract
Biological aging is a rapidly growing area of research, which entails characterizing the rate of aging independent of an individuals chronological age. In this review, we analyze the results of biological aging research in 435 papers published in a twelve year window, revealing changing patterns of molecular markers of biological aging use over time, and the development of novel metrics of biological aging. We further identify consistent and discordant research findings, as well as areas of potential future research focusing on questions of measurement with methylation or biomarker-based assessment and other variables relevant to the study of biological age.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper provides a comprehensive review of biological aging, focusing on molecular markers and metrics, which are crucial for understanding the underlying mechanisms of aging. While it offers solid insights into the evolving landscape of biological aging research, its nature as a review limits its impact to a solid contribution rather than groundbreaking findings. The identification of research gaps and future directions is valuable, but it does not present novel experimental data or transformative insights that would significantly advance the field.
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