Impaired axon regeneration and heightened synaptic dynamics in the injured aged mammalian cortex
Abstract
How aging affects axon regeneration and synaptic repair in the brain is poorly understood. To study age-related changes in neural circuits, we developed a model of axonal injury in the aged (> 2 years) mouse somatosensory cortex. By directly tracking fluorescently labelled injured axons by multiphoton imaging, we find that while axon degeneration in the aged brain is comparable to the young adult brain, axon regeneration is impaired. We further examine changes in the most common type of cortical synapses, En Passant Boutons (EPBs), and observe a transient and significant increase in the number and size of boutons 6 hours post-lesion. Using a computational model of a recurrent neural network, we examined the functional consequences of these synaptic increases on memory, comparing results to models of the young adult brain. The results suggest that increased synaptic dynamics might enable partial recovery from injury via synaptic re-wiring in the aged brain.
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Research summary
The paper investigates age-related changes in axon regeneration and synaptic dynamics, which are critical aspects of understanding the aging process in the brain. While it provides solid research on the mechanisms of neural repair in aged mammals, the findings primarily contribute to the understanding of age-related changes rather than addressing the root causes of aging or lifespan extension. Thus, while it is relevant to longevity research, its impact is limited as it does not propose significant advancements or solutions to aging itself.
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