Biometric Aging Clock for Practical Utility in Clinical Settings
Abstract
Aging clocks are an essential tool for biogerontological research that enables a quick assessment of one's pace of aging. In research settings, clocks trained on -omics data types are the most popular since they allow for an inspection of the most basic cellular processes of aging. In clinical settings, however, omics biomarkers of aging are impractical since they are linked to extra logistical load and costs, and they require personnel training. In this article, we present a cost-efficient aging clock that can be implemented easily in most clinics and hospitals to measure patients' aging rates. The clock requires only 22 biomarkers, including 17 blood test parameters, and four biometric measures (blood pressure, body mass index, and waist circumference). The clock predicts one's chronological age with a mean average error of 7.35 years, and it reveals associations with hypertension, cancer, and obesity.
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Research summary
The paper presents a cost-efficient aging clock that predicts chronological age using 22 biomarkers. This research is relevant as it aims to provide a practical tool for assessing aging rates in clinical settings, which could contribute to understanding and potentially addressing age-related health issues.
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