The China Brain Multi-omics Atlas Project (CBMAP)

Zhou, D., Zhou, Y., Sun, Z., Ji, F., Zhang, D., Wang, Q., Ruan, Y., Wang, Y., Zhu, Y., Sun, X., Li, M. J., Yuan, C., Liu, K., Sun, L., Zhai, W., Fan, J., Zhu, K., Qiu, W., Yan, X., Ma, C., Shen, Y., Bao, A., Yue, W., Shi, Y., Chen, C., Yang, J., Duan, S., Zhang, J.

School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaSchool of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China · biorxiv

Paper

Abstract

The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1,000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of East Asian populations in brain research. By integrating genome, epigenome, transcriptome, proteome (including multiple post-translational modifications), and metabolome data, CBMAP is set to provide a rich and invaluable resource for investigating the molecular underpinnings of aging-related brain phenotypes and neuropsychiatric disorders. Leveraging high-throughput omics data and advanced technologies, such as spatial transcriptomics, proteomics, and single-nucleus 3D chromatin structure analysis, this atlas will serve as a crucial resource for the brain science community, illuminating disease mechanisms and enhancing the utility of data from genome-wide association studies (GWAS). CBMAP is also poised to accelerate drug discovery and precision medicine for brain disorders.

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Research summary

The CBMAP aims to create a comprehensive molecular reference map of human brains to investigate the molecular underpinnings of aging-related brain phenotypes. This project addresses the root causes of aging by integrating multi-omics data to enhance understanding of neuropsychiatric disorders and aging mechanisms.

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