Sex-specific insights into drug-induced lifespan extension and weight loss in mice

Belikov, A. V., Talay, A., de Magalhaes, J. P.

Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK · biorxiv

Paper

Abstract

The DrugAge database serves as a comprehensive resource for the study of compounds that increase lifespan in model organisms. In the latest version of DrugAge, we have implemented multiple updates, predominantly focusing on mouse (Mus musculus) studies to enhance data accuracy and consistency. Key improvements include the re-recording of mouse data from original sources, standardization of drug dosages to parts per million (ppm), and detailed recording of administration routes, treatment initiation ages, and durations. The user interface has also been upgraded. Additionally, weight change data were included to address the potential impact of caloric restriction induced by drug administration on lifespan. Our analysis revealed significant correlations between weight loss and lifespan extension in male mice, particularly in studies conducted by the Interventions Testing Program (ITP), highlighting the importance of considering weight change in lifespan studies. We also observed notable sex-related differences in lifespan and weight change responses, underscoring the need for gender-specific analyses in aging research.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper is relevant to longevity research as it investigates drug-induced lifespan extension in mice, focusing on the relationship between weight loss and lifespan, which are critical factors in aging studies. However, the findings appear to be incremental and primarily emphasize the importance of sex-specific analyses rather than presenting groundbreaking insights or novel interventions that could significantly advance the field.

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