Aging macaques bridge the translational gap in perivascular space biology

Liguore, W. A., Schwartz, D. L., Piantino, J., Rajendran, A., Jensen, G., Karpf, J. A., Chernov, M. M., Woltjer, R. L., Kohama, S. G., Silbert, L. C., Weiss, A. R.

OHSU/ONPRCOHSU/ONPRC · biorxiv

Paper

Abstract

The prevalence of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5-28 years of age demonstrated a robust association between age and PVS burden, with an anatomical distribution paralleling that of humans. Preliminary ex vivo validation confirmed that the MRI-detected tubular structures correspond to perivascular spaces. These findings establish the rhesus macaque as a tractable model for understanding the role of perivascular dysfunction in age-related brain vulnerability.

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Research summary

The study identifies a robust association between age and perivascular space burden in macaques, suggesting a model for understanding age-related brain vulnerability. The research explores biological mechanisms related to aging, which is pertinent to longevity studies.

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