Microbiome-host interactions drive a trade-off between sleep quality and lifespan in Drosophila

BHARGAVA, P., Chen, S., Lee, J., Yoshinari, Y., Nishimura, T., Ushio, M., Sugiura, Y., Cheng, K. F., Fung, Y. S., Hase, K., Nakamura, H., Enomoto, M., Kim, J., Johnson, H. E., Liao, Y., Hirano, Y.

Division of Life Science, The Hong Kong University of Science and Technology; Clear Water Bay, Kowloon, Hong Kong SAR, China, School of Biological Sciences, Fac · biorxiv

Paper

Abstract

Understanding the interactions between various aging processes and the resulting heterogeneity in aging is crucial for promoting healthy aging. Here, we provide evidence that heterogeneity in microbiome and host interactions contributes to diversifying aging phenotypes in sleep, gut integrity, and longevity in Drosophila. Aged flies exhibiting sleep fragmentation preserve gut integrity, accompanied by a shift in microbiota composition, particularly an increase in Acinetobacter junii. A. junii induces sleep fragmentation via its metabolite, urocanic acid, through serotonin receptor-dependent dopamine upregulation. In parallel, A. junii exploits the host response to promote its growth, leading to lifespan extension, which is recapitulated by genetically modified Escherichia coli, suggesting a trade-off between sleep quality and lifespan. Our study demonstrates a systematic mechanism underlying aging heterogeneity, suggesting interventions through bacterial supplements.

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Research summary

The paper claims that microbiome-host interactions create a trade-off between sleep quality and lifespan in Drosophila. This research is relevant as it explores the underlying mechanisms of aging and longevity, focusing on how microbiome composition can influence aging phenotypes and lifespan, which could lead to potential interventions for promoting healthy aging.

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