Longevity Papers

Week of February 10 - February 16, 2025
Weekly AI-generated podcast
March 13 episode:
Sunday, February 16, 2025
Sharma, A., Mistry, M., Yao, P. ... · cell biology · Harvard T. H. Chan School of Public Health · biorxiv
Aging results in a loss of metabolic flexibility during fasting, characterized by the inability to acutely switch between metabolic substrates and reduced lipid mobilization. However, the drivers of these effects intracellularly remain unclear. Here, in Caenorhabditis elegans, we...
Yu Yang Ng, Andy Tay · Aging cell · Department of Biomedical Engineering, National University of Singapore, Singapore City, Singapore. · pubmed
Ageing is an inevitable biological process that impacts the immune system, leading to immunosenescence and inflammaging, which contribute to increased susceptibility to infections, autoimmune diseases and cancers in individuals over the age of 65. This review focuses on the agein...
Xuming Zhu, Mingang Xu, Celine Portal ... · Meibomian Glands · Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. · pubmed
Meibomian glands secrete lipid-rich meibum, which prevents tear evaporation. Aging-related Meibomian gland shrinkage may result in part from stem cell exhaustion and is associated with evaporative dry eye disease, a common condition lacking effective treatment. The identities and...
Miny, S., Runel, G., Chlasta, J. ... · cell biology · CNRS - University Lyon1 · biorxiv
Skin homeostasis and self-renewal are partially maintained by interfollicular stem cells (ISCs), located in the basal layer above the dermal papillae of the dermo-epidermal junction (DEJ). Aging leads to a decline in skin renewal and a concurrent reduction in stem cell potential....
Laura Campello, Matthew J Brooks, Benjamin R Fadl ... · Aging cell · Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. · pubmed
Visual function deteriorates throughout the natural course of aging. Age-related structural and functional adaptations are observed in the retina, the light-sensitive neuronal tissue of the eye where visual perception begins. Molecular mechanisms underlying retinal aging are stil...
Saturday, February 15, 2025
R Moaddel, J Candia, C Ubaida-Mohien ... · Aging cell · Biomedical Research Centre, National Institute on Aging, NIH, Baltimore, Maryland, USA. · pubmed
The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive physiological and functional manifestations of aging. However, most of these studies were limited to examining one biological compartment, an approach that fails to ...
Das, P., Ravi, R., Singh, J. · physiology · Indian Institute of Science Education and Research Mohali, India · biorxiv
Gut microbes play a crucial role in modulating host lifespan. However, the microbial factors that influence host longevity and their mechanisms of action remain poorly understood. Using the expression of Caenorhabditis elegans FAT-7, a stearoyl-CoA 9-desaturase, as a proxy for li...
Menzel, L., Zschummel, M., O'Melia, M. J. ... · immunology · Edwin L. Steele Laboratories, Massachusetts General Hospital, Harvard Medical School · biorxiv
A diverse naive CD8 T cell repertoire is essential to provide broad protection against infection and cancer. Aging diminishes naive T cells, reducing potential diversity and leading to lymph node contraction. Here, we revealed that this decline occurs earlier in males, resulting ...
Friday, February 14, 2025
Xin Huang, Chenzhong Xu, Jie Zhang ... · Myostatin · Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), National Engineering Research Center for Biotechnology (Shenzhen), International Cancer Center, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, China. · pubmed
Exercise can improve health via skeletal muscle remodeling. Elucidating the underlying mechanism may lead to new therapeutics for aging-related loss of skeletal muscle mass. Here, we show that endurance exercise suppresses expression of YT521-B homology domain family (Ythdf1) in ...
Amanda E Coleman, Kate E Creevy, Rozalyn Anderson ... · GeroScience · Department of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA. [email protected]. · pubmed
Companion dogs are a powerful model for aging research given their morphologic and genetic variability, risk for age-related disease, and habitation of the human environment. In addition, the shorter life expectancy of dogs compared to human beings provides a unique opportunity f...
Angela M Tuckowski, Safa Beydoun, Elizabeth S Kitto ... · eLife · Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, United States. · pubmed
Flavin-containing monooxygenases (FMOs) are a conserved family of xenobiotic enzymes upregulated in multiple longevity interventions, including nematode and mouse models. Previous work supports that
Tianyuan Gu, Yong He, Jianan Zhou ... · Nucleus Pulposus · Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. · pubmed
Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding of disease mechanisms. In this study, we report that circFUNDC1, a nuclear circular RNA, is markedly downregulated in nucleus pulposus...
Qiuting Wen, Joseph Muskat, Charles F Babbs ... · Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. · pubmed
Intracranial cardiac impulse propagation along penetrating arterioles is vital for both nutrient supply via blood circulation and waste clearance via CSF circulation. However, current neuroimaging methods are limited to simultaneously detecting impulse propagation at pial arterie...
Severin Haider, Eliza Sassu, Dragana Stefanovska ... · Enteric Nervous System · Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany. · pubmed
Aging strongly affects the peripheral nervous system (PNS), triggering alterations that vary depending on the innervated tissue. The most frequent alteration in peripheral nerve aging is reduced nerve fiber and glial density which can lead to abnormal nerve functionality. Interes...
Thursday, February 13, 2025
Danitra Parker, Kanisa Davidson, Pawel A Osmulski ... · Aging cell · Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA. · pubmed
The aging brain experiences a significant decline in proteasome function. The proteasome is critical for many key neuronal functions including neuronal plasticity, and memory formation/retention. Treatment with proteasome inhibitors impairs these processes. Our study reveals a ma...
Ying Zou, Mibu Cao, Meiling Tai ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China. · pubmed
The decrease in fibroblast collagen is a primary contributor to skin aging. Lactate can participate in collagen synthesis through lysine lactylation by regulating gene transcription. However, the precise mechanism by which lactate influences collagen synthesis requires further in...
Lei Qi, Jing Wang, Jinge Yan ... · Journal of nanobiotechnology · Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai, 200011, PR China. · pubmed
Senescent mandibular bone repair poses a formidable challenge without a completely satisfactory strategy. Endogenous cell recruitment and osteogenic differentiation are two sequential stages in bone regeneration, and disruptions in these two processes present significant obstacle...
Cui Guan, Abigail Otchere, Mihails Laskovs ... · Aging cell · College of Health and Life Sciences, Aston University, Birmingham, UK. · pubmed
Invertebrate models have been instrumental in advancing our understanding of the molecular mechanisms of ageing. The isolation of single gene mutations that both extend lifespan and improve age-related health have identified potential targets for therapeutic intervention to allev...
Vera Middelkamp, Eliisa Kekäläinen · GeroScience · Translational Immunology Research Program and Dept. of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. · pubmed
Age-associated thymic involution leads to a significant decline in thymic T cell output, a major contributor to immunosenescence in the elderly. Accurately measuring thymic output is therefore critical for understanding the mechanisms behind immune aging. Furthermore, robust quan...
Yehui Gao, Xinyun Zhang, Congmin Wei ... · Aging cell · School of Life Sciences and Technology, Shanghai East Hospital, Institute for Regenerative Medicine, Tongji University, Shanghai, China. · pubmed
As global life expectancy increases, the focus has shifted from merely extending lifespan to promoting healthy aging. GSTA1, GSTA2, and GSTA3 (GSTA1-3), members of the alpha class of glutathione S-transferases, are involved in diverse biological processes, including metabolism an...
Sivakumar, S., LeFebre, R., Menichetti, G. ... · bioengineering · University of Pittsburgh · biorxiv
Maintenance of organismal function requires tightly regulated biomolecular communication. However, with aging, communication deteriorates, thereby disrupting effective information flow. Using information theory applied to skeletal muscle single cell RNA-seq data from young, middl...
Robinson, T. D., Sun, Y. L., Chang, P. T. H. ... · neuroscience · Rotman Research Institute, Baycrest · biorxiv
One of the most promising interventional targets for brain health is cerebral perfusion, but its link to white matter (WM) aging remains unclear. Motivated by existing literature demonstrating links between declining cortical perfusion and the development of WM hyperintensities, ...
Wednesday, February 12, 2025
Zhi-Peng Li, Zhaozhen Du, De-Shuang Huang ... · Deep Learning · Ningbo Institute of Digital Twin, Eastern Institute of Technology, Ningbo, 315201, Zhejiang, China. · pubmed
Deep learning (DL) and explainable artificial intelligence (XAI) have emerged as powerful machine-learning tools to identify complex predictive data patterns in a spatial or temporal domain. Here, we consider the application of DL and XAI to large omic datasets, in order to study...
Man Zhu, Meng Ma, Lunan Luo ... · Aging cell · Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. · pubmed
DNA topoisomerases are essential molecular machines that manage DNA topology in the cell and play important roles in DNA replication and transcription. We found that knocking down the enzyme topoisomerase Top2 or its mammalian homolog TOP2B increases the lifespan of S. cerevisiae...
Jian Zhang, Shunze Jia, Zehua Zheng ... · GeroScience · First Affiliated Hospital, Zhejiang University School of Medicine, and Liangzhu Laboratory of Zhejiang University, Hangzhou, Zhejiang, China. · pubmed
The ovary is one of the first organs in humans to exhibit age-related functional impairments. As an organ composed of diverse heterogeneous cell types, the ovary exhibits cell-type-specific changes during the aging process, ultimately leading to a decline in female fertility. Inv...
Felipe Cabral-Miranda, Ana Paula Bergamo Araujo, Danilo Bilches Medinas ... · Aging cell · Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. · pubmed
Dementia, characterized by loss of cognitive abilities in the elderly, poses a significant global health challenge. This study explores the role of astrocytes, one of most representative glial cells in the brain, in mitigating cognitive decline. Specifically, we investigated the ...
Xin Fu, Yu Zhao, Xiwei Cui ... · Chemokine CXCL9 · Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, P. R. China. · pubmed
Microvascular aging, predominantly driven by endothelial cells (ECs) dysfunction, is a critical early event in cardiovascular diseases. However, the specific effects of aging on ECs across the microvascular network segments and the associated mechanisms are not fully understood. ...
Xiao Li, Yao Xu, Ting Li ... · Aging · Department of Pathology, Wuhan No. 1 Hospital, Wuhan 430022 China. · pubmed
Cognitive impairment is a typical hallmark of aging in mice and humans. Here, we reported that downregulation of STAT1 improved learning and memory impairments in aging mice by enhancing the expression of synaptic protein and inhibiting the expression of inflammatory factors. Pro...
M Borri, M E Jacobs, P Carmeliet ... · American journal of physiology. Renal physiology · Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, Leuven, 3000, Belgium. · pubmed
Global population aging is an escalating challenge in modern society, especially as it impairs the function of multiple organs and increases the burden of age-related diseases. The kidneys, in particular, experience function decline, reduced regenerative capacity and increased su...
Yuting Chen, Jiaxin Hu, Pengwei Zhao ... · Nature cell biology · Department of Biochemistry and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. · pubmed
Ribophagy is a selective autophagic process that regulates ribosome turnover. Although NUFIP1 has been identified as a mammalian receptor for ribophagy, its homologues do not exist in yeast and nematodes. Here we demonstrate that Rpl12, a ribosomal large subunit protein, function...
Tuesday, February 11, 2025
Morris, S., Schmelter, F., Molina Riquelme, I. E. ... · cell biology · University of Muenster · biorxiv
Heart disease is the leading cause of death in the elderly population and the heart is a highly energy-consuming tissue. Aging-related heart failure is often driven by energy depletion in cardiomyocytes (CM), which rely on their abundant, cristae-dense mitochondria for ATP produc...
Shohreh Teimuri, Beat Suter · RNA, Messenger · Institute of Cell Biology, University of Bern, Berne, Switzerland. · pubmed
Topoisomerase 3β (Top3β) works not only on DNA but also on RNA. We isolated and identified the naturally cross-linked RNA targets of Drosophila Top3β from an early embryonic stage that contains almost exclusively maternal mRNAs. Favorite targets were long RNAs, particularly with ...
Liu, H., Yuan, L., GV, S. · cell biology · ETH Zurich and Paul Scherrer Institut · biorxiv
Robust 3D tissue culture models to activate aged fibroblasts for cell-based therapies and identify regulators of such activation are still missing. In our previous study, we showed that aged fibroblasts can be activated simply through applying compressive force, without the need ...
Min Li, Bo Chen, Sibo Sun ... · Cell proliferation · Department of Geriatrics, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. · pubmed
Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation and senescence. Previous studies showed that club cells and club cell secretory proteins (CCSP) have anti-inflammatory roles, which reduced in COPD. Klotho (KL) decreased in human COPD lung tiss...
He, X., Zhang, H., Wang, Y. ... · developmental biology · State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Clinical Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical · biorxiv
The decline in oocytes quality and developmental potential with female reproductive aging is well recognized, yet the underlying mechanisms remain insufficiently investigated. In this study, through an integrative analysis of transcriptomes and morphologies of individual oocytes ...
Goldberg, D. C., Cloud, C., Lee, S. M. ... · genomics · Children\\\'s Hospital of Philadelphia · biorxiv
Epigenome-wide association studies (EWAS) are transforming our understanding of the interplay between epigenetics and complex human traits and phenotypes. We introduce the Methylation Screening Array (MSA), a new iteration of the Infinium technology for scalable and quantitative ...
Henriette Thau, Bastian P Gerjol, Katharina Hahn ... · Skin Aging · Van Cleve Cardiac Regenerative Medicine Program Mayo Clinic, Rochester, Minesota, USA; Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. · pubmed
Skin aging represents a multifactorial process influenced by both intrinsic and extrinsic factors, collectively known as the skin exposome. Cellular senescence, characterized by stable cell cycle arrest and secretion of pro-inflammatory molecules, has been implicated as a key dri...
Li, Y., Goodrich, J. M., Peterson, K. E. ... · epidemiology · Rutgers- The State University of New Jersey (All Campuses) · medrxiv
DNA methylation (DNAm) is a chemical modification of DNA that can be influenced by various factors, including age, environment, and lifestyle. An epigenetic clock is a predictive tool that measures biological age based on DNAm levels. It can provide insights into an individual's ...
Monday, February 10, 2025
Fang Yu, Changhan Chen, Wuping Liu ... · Aging cell · Department of Neurology, Central South University, Changsha, China. · pubmed
Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging-related diseases. It has long been speculated that "rejuvenation molecules" exist in their blood to promote extended lifespan. We unexpectedly discovered that longevity i...
Doherty, T., McDermott, E., Delany, S. J. ... · bioinformatics · Technological University Dublin · biorxiv
Background: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders with a dysregulated immune response partly influenced by environmental factors. DNA methylation (DNAm), a key epigenetic mechanism, is implicated in the etiology of complex diseases, including IBD. ...
Qiaowei Li, Qin Liu, Zhong Lin ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Shengli Clinical Medical College of Fujian Medical University, Fuzhou, P.R.China. · pubmed
The impact of mid-late-life exercise on the aging heart remains unclear, particularly the effects of high-intensity interval training (HIIT) and continuous moderate-intensity training (CMIT). This study was the first to examine cardiac function, tissue characteristics, electrical...
Ye, Q., Ahamed, A., Shalev, I. ... · obstetrics and gynecology · Duke University · medrxiv
Evolutionary theories of aging indicate trade-offs between reproduction and longevity. Epigenetic clocks, such as PhenoAge, GrimAge, and DunedinPoAm, were designed to reflect biological age and be used as surrogates for mortality and healthspan. The current study investigated the...
Manish Kumar, Abhishek Singh Sengar, Anushree Lye ... · Reactive Oxygen Species · Centre of Biomedical Research, Raebareli Road, Lucknow, Uttar Pradesh, 226014, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. · pubmed
Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though the etiology of doxorubicin-dependent heart damage has yet to be fully elucidated, the ability of doxorubicin to damage DNA and trigger oxidative stress have been h...
Takayasu, L., Watanabe, E., Umeyama, T. ... · microbiology · RIKEN · biorxiv
The temporal changes of the gut microbiome are thought to be critical for understanding its interactions with host aging, but lifelong dynamics within the same individual remain largely unknown. Here we firstly report the high temporal resolution dynamics of gut microbiomes in mi...
Strzelczyk, D., Peylo, C., Langer, N. · neuroscience · University of Zurich · biorxiv
Aging is associated with cognitive decline and memory impairment, but the underlying neural mechanisms remain unclear. Phase-amplitude coupling (PAC) between mid-frontal theta (5 Hz) and occipital gamma (>30 Hz) oscillations is a proposed marker for parallel storage of multiple i...
Sabira Mohammed, Phoebe Ohene-Marfo, Chao Jiang ... · GeroScience · Stephenson Cancer Center, Department of Biochemistry and Physiology, Oklahoma Center for Geroscience & Brain Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA. · pubmed
Chronic, low-grade inflammation is a hallmark of aging and various age-related diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). The prevalence of metabolic dysfunction-associated steatohepatitis (MASH), an advanced form of MASLD, increases wit...
Tayler N LaSharr, Samantha P H Dwinnell, Rhiannon P Jakopak ... · Reproduction · Haub School of Environment and Natural Resources, University of Wyoming, Bim Kendall House, 804 E Fremont St., Laramie, WY, 82072, USA. [email protected]. · pubmed
Deterioration in nutritional condition with aging could reduce reproductive success but coincides with declines in residual reproductive potential, thus invoking opposing expectations for late-life reproduction. Yet, the mechanisms regulating energy accrual and allocation to repr...
Patricia L Opresko, Samantha L Sanford, Mariarosaria De Rosa · Cold Spring Harbor perspectives in biology · Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA [email protected]. · pubmed
Oxidative stress is associated with increasing telomere shortening and telomere dysfunction, as well as with numerous pathologies in humans, including inflammatory diseases and cancer. Critically short and dysfunctional telomeres lose their ability to protect chromosome ends, whi...
Quetzalli D Angeles-Lopez, Jhonny Rodriguez-Lopez, Paula Agudelo Garcia ... · Fatty Acids · Department of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA. · pubmed
Idiopathic pulmonary fibrosis (IPF) is an age-related interstitial lung disease, characterized by inadequate alveolar regeneration and ectopic bronchiolization. While some molecular pathways regulating lung progenitor cells have been described, the role of metabolic pathways in a...
Jiasheng Wang, Peng Guo, Dongmei Wu ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China. · pubmed
Osteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology is related to the local accumulation of senescent cells (SnCs). However, existing SnCs-scavenging drugs "senolytics" may lead to the exhaustion of stem and proge...
Nadour, M., LEATIS, R. I. V. R., BIARD, M. ... · developmental biology · UQAM · biorxiv
Neuronal architecture established embryonically must persist lifelong to ensure normal brain function. However, little is understood about the mechanisms behind the long-term maintenance of neuronal organization. To uncover maintenance mechanisms, we performed a suppressor screen...
Falcsik, G., Keresztes, F., Balod, T. M. ... · genetics · Department of Genetics, Eotvos Lorand University (ELTE), Budapest, Hungary · biorxiv
Macroautophagy (hereafter referred to as autophagy) is an important self-renewal process in our cells, whereby potentially harmful cellular components are encapsulated within a double-membrane autophagosome and subsequently fused with a lysosome for degradation by acidic hydrolas...
Yosra Bejaoui, Luma Srour, Abeer Qannan ... · GeroScience · College of Health and Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar. · pubmed
Several progeroid syndromes' causative mutations have been linked to epigenetic age acceleration as measured via several epigenetic clocks. At the same time, several protective variants have also been discovered that can reduce the risk of developing certain age-related disorders...